AAC 00155 - 10 revised version 1 2 Overexpression of Resistance - Nodulation - Cell Division Pump 3 AdeFGH confers Multidrug Resistance in Acinetobacter 4 baumannii
نویسندگان
چکیده
6 Sébastien Coyne, 1 Nicolas Rosenfeld, 1 Thierry Lambert, 1,2 Patrice Courvalin, 1* and Bruno 7 Périchon 1 8 9 Institut Pasteur, Unité des Agents Antibactériens, 75724 Paris Cedex 15, 1 and Centre 10 d’Etudes Pharmaceutiques, Châtenay-Malabry, 2 France 11 12 Running title: AdeFGH efflux pump of A. baumannii 13 14 * Corresponding author: 15 Patrice Courvalin 16 Tel.: (33) (1) 45 68 83 20 17 Fax: (33) (1) 45 68 83 19 18 e-mail: [email protected] 19 20
منابع مشابه
Revised manuscript AAC 01388 - 10 1 Efflux - Mediated Antibiotic Resistance in Acinetobacter spp . 2 3 4
24 Among Acinetobacter spp., A. baumannii is the most frequently implicated in nosocomial 25 infections, in particular in intensive care units. It was initially thought that multidrug 26 resistance (MDR) in this species was mainly due to horizontal acquisition of resistance genes. 27 However, it has become recently obvious that increased expression of chromosomal genes for 28 efflux systems pla...
متن کاملRND-type efflux pumps in multidrug-resistant clinical isolates of Acinetobacter baumannii: major role for AdeABC overexpression and AdeRS mutations.
Increased expression of chromosomal genes for resistance-nodulation-cell division (RND)-type efflux systems plays a major role in the multidrug resistance (MDR) of Acinetobacter baumannii. However, the relative contributions of the three most prevalent pumps, AdeABC, AdeFGH, and AdeIJK, have not been evaluated in clinical settings. We have screened 14 MDR clinical isolates shown to be distinct ...
متن کاملGenome Sequence of a Clinical Strain of Acinetobacter baumannii Belonging to the ST79/PFGE-HUI-1 Clone Lacking the AdeABC (Resistance-Nodulation-Cell Division-Type) Efflux Pump
Increased expression of chromosomal genes for resistance-nodulation-cell division-type efflux systems plays a major role in the multidrug resistance of Acinetobacter baumannii Little is known about the genetic characteristics of clinical strains of Acinetobacter baumannii lacking the AdeABC pump. In this study, we sequenced the genome of clinical strain Ab421 GEIH-2010 (belonging to clone ST79/...
متن کاملContribution of efflux pumps, porins, and β-lactamases to multidrug resistance in clinical isolates of Acinetobacter baumannii.
We investigated the mechanisms of resistance to carbapenems, aminoglycosides, glycylcyclines, tetracyclines, and quinolones in 90 multiresistant clinical strains of Acinetobacter baumannii isolated from two genetically unrelated A. baumannii clones: clone PFGE-ROC-1 (53 strains producing the OXA-58 β-lactamase enzyme and 18 strains with the OXA-24 β-lactamase) and clone PFGE-HUI-1 (19 strains s...
متن کاملبررسی بیان و عملکرد ژن پمپ‌های افلاکس ایزوله‌های مقاوم به چند دارو در اسینتوباکتر بامانی غیرکلونال
Abstract Background: Efflux systems are components of the bacterial membrane that play a role in homeostasis of the cell and extrusion of toxic compounds. Efflux pumps of the resistance nodulation cell division (RND) superfamily, confer multidrug resistance to their host when over-expressed. One of the RND efflux systems, is AdeABC which have been characterized for A. baumannii. Another pump be...
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تاریخ انتشار 2010